Between Prague and Mainz we found 0 direct bus departures, if connection travel options are available you can find them listed below. Alternatively we recommend that you search for buses from larger cities near Prague or from Prague to larger cities near Mainz.
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Traveling by bus from Prague to Mainz
The shortest travel distance between Prague (CZ) and Mainz (DE) is 546 km, which equals a travel time by car of about 05:28 h.
Departure and arrival station(s)
You can see information about the departure station and stops Prague here
You can see information about the arrival station and stops Mainz here