Between Karlsruhe and Nis we found 0 direct bus departures, if connection travel options are available you can find them listed below.
Alternatively we recommend that you search for buses from larger cities near Karlsruhe or from Karlsruhe to larger cities near Nis.
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Traveling by bus from Karlsruhe to Nis
The shortest travel distance between Karlsruhe (DE) and Nis (RS) is 1474 km, which equals a travel time by car of about 13:56 h.