Between Rome and Madrid we found 0 direct bus departures, if connection travel options are available you can find them listed below. Alternatively we recommend that you search for buses from larger cities near Rome or from Rome to larger cities near Madrid.
Traveling by bus from Rome to Madrid
The shortest travel distance between Rome (IT) and Madrid (ES) is 1970 km, which equals a travel time by car of about 19:06 h.
Departure and arrival station
You can see information about the departure station and stops Rome here
You can see information about the arrival station and stops Madrid here