Between Madrid and Karlsruhe we found 0 direct bus departures, if connection travel options are available you can find them listed below.
Alternatively we recommend that you search for buses from larger cities near Madrid or from Madrid to larger cities near Karlsruhe.
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Traveling by bus from Madrid to Karlsruhe
The shortest travel distance between Madrid (ES) and Karlsruhe (DE) is 1718 km, which equals a travel time by car of about 15:45 h.
Departure and arrival station(s)
You can see information about the departure station and stops Madrid here
You can see information about the arrival station and stops Karlsruhe here