Between Karlsruhe and Madrid we found 0 direct bus departures, if connection travel options are available you can find them listed below.
Alternatively we recommend that you search for buses from larger cities near Karlsruhe or from Karlsruhe to larger cities near Madrid.
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Traveling by bus from Karlsruhe to Madrid
The shortest travel distance between Karlsruhe (DE) and Madrid (ES) is 1716 km, which equals a travel time by car of about 15:42 h.
Departure and arrival station(s)
You can see information about the departure station and stops Karlsruhe here
You can see information about the arrival station and stops Madrid here