Between Rome and Brussels we found 0 direct bus departures, if connection travel options are available you can find them listed below. Alternatively we recommend that you search for buses from larger cities near Rome or from Rome to larger cities near Brussels.
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Traveling by bus from Rome to Brussels
The shortest travel distance between Rome (IT) and Brussels (BE) is 1482 km, which equals a travel time by car of about 14:55 h.
Departure and arrival station(s)
You can see information about the departure station and stops Rome here
You can see information about the arrival station and stops Brussels here